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Kir2.1 (KCNJ2) Polyclonal Antibody, Invitrogen™

Product Code. 17179723
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50 μL
Unit Size:
50µL
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17179723 50 μL 50µL
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Product Code. 17179723 Supplier Invitrogen Supplier No. PA5111812

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Guinea Pig Polyclonal Antibody

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: (C)NGVPEST STDTPPDIDL HN Homology: Rabbit, bovine, pig, guinea pig amino acid residues identical; rat, mouse - 17/19 amino acid residues identical; chicken - 15/19 amino acid residues identical.

The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kir2.1 (KCNJ2)
Applications Western Blot
Classification Polyclonal
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.05% sodium azide; pH 7.4
Gene Kcnj2
Gene Accession No. P35561, P63252, Q64273
Gene Alias ATFB9; Cardiac inward rectifier potassium channel; EGK_08925; HHBIRK1; HHIRK 1; HHIRK1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; Inward rectifier potassium channel 2; IRK 1; IRK1; IRK-1; IRK2; Kcnf1; KCNJ2; KIR2.1; LQT 7; LQT7; Potassium channel, inwardly rectifying subfamily J member 2; SQT 3; SQT3
Gene Symbols Kcnj2
Host Species Guinea Pig
Immunogen Peptide corresponding to amino acid residues 392-410 of human Kir2.1 (Intracellular, C-terminus)
Purification Method Antigen affinity chromatography
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16518, 29712, 3759
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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