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Kartogenin, MedChemExpress

Product Code. 16457076
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Product Code. 16457076

Brand: Medchem Express HY16268

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Description

MedChemExpress Kartogenin (KGN) is an inducer of differentiation of human mesenchymal stem cells into chondrocytes, with an EC50 of 100 nM. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. Kartogenin can be used for the research of osteoarthritis (OA).

Kartogenin (KGN) is an inducer of differentiation of human mesenchymal stem cells into chondrocytes, with an EC50 of 100 nM. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. Kartogenin can be used for the research of osteoarthritis (OA).

Specifications

Chemical Name or Material Kartogenin
Physical Form Powder
CAS 4727-31-5
Color Off-White
Quantity 100 mg
Purity Grade Notes Research
Molecular Formula C20H15NO3
Synonym KGN
Solubility Information DMSO : ≥ 42 mg/mL (132.35 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
Molecular Weight (g/mol) 317.34
Formula Weight 317.34
Percent Purity 95.0%
Grade Research
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Research purposes only

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