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Itacitinib, MedChemExpress

Product Code. p-200097654
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Product Code. 16497248 Supplier Medchem Express Supplier No. HY16997

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Description

MedChemExpress Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1 with an IC50 of 2 nM for human JAK1. Itacitinib shows >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.

Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1 with an IC50 of 2 nM for human JAK1. Itacitinib shows >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2

Specifications

Chemical Name or Material Itacitinib
CAS 1334298-90-6
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C26H23F4N9O
Quantity 10 mg
Synonym INCB039110
Solubility Information DMSO : ≥ 30 mg/mL (54.20 mM)
SMILES N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1
Molecular Weight (g/mol) 553.51
Formula Weight 553.51
Percent Purity 98.02%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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