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Integrin beta 7 Antibody (FIB27), DyLight 594, Novus Biologicals™

Rabbit Monoclonal Antibody

Brand:  Novus Biologicals NBP2-81087DL594

Additional Details : Weight : 0.00970kg

Product Code. 18331421

  • 588.54 EUR / 0.10mL
Estimated Shipment: 18-07-2024
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Description

Description

Integrin beta 7 Monoclonal specifically detects Integrin beta 7 in Human, Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.
Specifications

Specifications

Integrin beta 7
Monoclonal
DyLight 594
50mM Sodium Borate
ITGB7
FIB27 was prepared by immunizing rats with TK1 cells.
0.1 mL
Signal Transduction
3695
Human, Mouse
Purified
Flow Cytometry, Immunocytochemistry, Immunofluorescence
FIB27
Flow Cytometry, Immunocytochemistry/Immunofluorescence
Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
Rabbit
Protein A purified
RUO
Primary
FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
Store at 4°C in the dark.
IgG κ
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