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IL12A Monoclonal Antibody (OTI1G5), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA808129
This item is not returnable.
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Description
IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.Specifications
| IL12A | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P29459 | |
| IL12A | |
| Human recombit protein fragment corresponding to amino acids 57-253 of human IL12A produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI1G5 | |
| Unconjugated | |
| IL12A | |
| CLMF, IL-12A, NFSK, NKSF1, P35 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 3592 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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