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Invitrogen™ Human TRAF4 (aa 161-258) Control Fragment Recombinant Protein

Product Code. 30194479
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Quantity:
100 μL
Unit Size:
100µL
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30194479 100 μL 100µL
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Product Code. 30194479 Supplier Invitrogen™ Supplier No. RP108742

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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (93%), Rat (93%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9BUZ4
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 9618
Name Human TRAF4 (aa 161-258) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias A530032M13Rik; Cart1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; Cysteine-rich motif associated to RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; msp2; RING finger protein 83; RNF83; RNF83malignant 62; TNF receptor associated factor 4; TNF receptor-associated factor 4; tnf receptor-associated factor 4 b; traf4; TRAF4 protein; TRAF4 variant 6; traf4b; tumor necrosis receptor-associated factor 4 A
Common Name TRAF4
Gene Symbol TRAF4
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence PQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCK
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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