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Invitrogen™ Human TCOF1 (aa 1045-1129) Control Fragment Recombinant Protein

Product Code. 30209877
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30209877

Brand: Invitrogen™ RP96814

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (37%), Rat (37%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58309 (PA5-58309. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q13428
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 6949
Name Human TCOF1 (aa 1045-1129) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias AA408847; AW209012; MFD1; nucleolar trafficking phosphoprotein; Tcof1; TCS; TCS1; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; treacle; Treacle protein; treacle ribosome biogenesis factor 1
Common Name TCOF1
Gene Symbol TCOF1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence ESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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