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Gibco™ Human IL-15 Receptor alpha (soluble) Fc Recombinant Protein, PeproTech®

Product Code. 17809255
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Quantity:
1 mg
100 μg
20 μg
250 μg
500 μg
Unit Size:
100µg
1mg
20µg
250µg
500µg
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Product Code. 17809255

Brand: Gibco™ 20015RA250UG

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Description

Recombinant Protein

Recombinant Human sIL-15 Receptor alpha Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL-15R alpha fused to the Fc portion of human IgG. Due to glycosylation, it migrates at an apparent molecular weight of 50-60 kDa, under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q13261
For Use With (Application) Functional Assay
Format Lyophilized
Formulation protein with no preservative
Gene ID (Entrez) 3601
Molecular Weight (g/mol) 44.4 kDa
Name Human IL-15 Receptor alpha (soluble) Fc
Purification Method HPLC, SDS-PAGE
Quantity 250 μg
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias AA690181; CD215; IL 15 receptor; IL 15 receptor subunit a; IL 15 R; IL 15 R alpha; IL 15 R a; IL15 receptor; IL15 receptor subunit alpha; IL-15 receptor subunit alpha; IL15 receptor subunit a; IL15R; IL15R alpha; IL15R a; Il15ra; IL-15 RA; IL-15 R-alpha; Interleukin 15 receptor; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4; interleukin 15 receptor alpha isoform IC5; interleukin 15 receptor alpha isoform IC6; interleukin 15 receptor alpha isoform IC7; interleukin 15 receptor alpha isoform IC8; interleukin 15 receptor subunit alpha; Interleukin 15 receptor subunit a; interleukin 15 receptor, alpha; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; sIL 15 R; sIL-15 receptor subunit alpha; sIL15R; sIL-15 RA; sIL-15 R-alpha; soluble IL 15 R; soluble IL15R; Soluble interleukin-15 receptor subunit alpha
Common Name IL15RA
Gene Symbol IL15RA
Biological Activity Determined by its ability to inhibit the proliferation of mouse CTLL-2 cells in the presence of Recombinant Human IL-15.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence ITCPPPMSVE HADIWVKSYS LYSRERYICN SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA KNWELTASAS HQPPGVYPQG HSDTTGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
Content And Storage -20°C
Activity Determined by its ability to inhibit the proliferation of mouse CTLL-2 cells in the presence of Recombinant Human IL-15.
Expression System Insect cells
Form Lyophilized
Purity or Quality Grade ≥98% by SDS-PAGE gel and HPLC analyses.
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