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STEMCELL Technologies Human Recombinant PDGF-CC

Product Code. p-7217821
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Quantity:
10 μg
50 μg
Unit Size:
10µg
50µg
This item is not returnable. View return policy

Product Code. 17139741

Brand: STEMCELL Technologies 78168

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This item is not returnable. View return policy

Description

Platelet-derived growth factor CC

  • The platelet-derived growth factor (PDGF) family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer
  • PDGF signals through the receptor tyrosine kinases PDGFRα and PDGFRβ
  • It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src and PI3K/AKT
  • PDGF is a potent mitogen for cells of mesenchymal origin such as fibroblasts and vascular smooth muscle cells
  • PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues
  • PDGF-CC is secreted as a latent growth factor and requires activation by proteolytic processing
  • PDGF-CC binds to PDGFRα homodimers and PDGFRαβ heterodimers, but not to PDGFRβ homodimers

Specifications

Name PDGF, Platelet-derived growth factor
Quantity 10 μg
Cell Type Mesenchymal Cells, PSC-Derived; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons; Osteoblasts; Other
Purity or Quality Grade ≥95%
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