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Invitrogen™ Human PLSCR1 (aa 1-27) Control Fragment Recombinant Protein

Product Code. 30211265
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Quantity:
100 μL
Unit Size:
100µL
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30211265 100 μL 100µL
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Product Code. 30211265 Supplier Invitrogen™ Supplier No. RP107665

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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (52%), Rat (52%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67025 (PA5-67025. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O15162
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 5359
Name Human PLSCR1 (aa 1-27) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1a; MmTRA1b; NOR1; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1; Plscr1; Tra1; Tra1a; Tra1b; transplantability-associated protein 1; Tras1; Tras2
Common Name PLSCR1
Gene Symbol PLSCR1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence MDKQNSQMNASHPETNLPVGYPPQYPP
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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