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Gibco™ Human HB-EGF Recombinant Protein, PeproTech®

Product Code. 17810853
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Product Code. Quantity unitSize
17810853 500 μg 500µg
17880923 100 μg 100µg
17891733 10 μg 10µg
17860753 1 mg 1mg
17851033 250 μg 250µg
17821743 50 μg 50µg
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Product Code. 17810853 Supplier Gibco™ Supplier No. 10047500UG

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Description

Recombinant Protein

Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q99075
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 1839
Molecular Weight (g/mol) 9.7 kDa
Name Human HB-EGF
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias AW047313; Diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DTR; DT-R; DTS; DTSF; GFHB; hb egf; HBEGF; Hb-egf; Hegfl; heparin binding EGF like growth factor; heparin binding epidermal growth factor-like growth factor; heparin-binding EGF-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor
Common Name HBEGF
Gene Symbol HBEGF
Biological Activity Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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