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Invitrogen™ HP1 alpha Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA582556
This item is not returnable.
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Description
Immunogen sequence: VVKGQVEYLL KWKGFSEEHN TWEPEKNLDC PELISEFMKK YKKMKEGENN KPREKSESNK RKSNFSNSAD DIKSKKKREQ SNDIARGFER GLEPEKIIGA TDSCGDLM Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 97%.
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
Specifications
| HP1 alpha | |
| Polyclonal | |
| Unconjugated | |
| Cbx5 | |
| 2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha) | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23468 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.10 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| P45973 | |
| Cbx5 | |
| Recombinant protein corresponding to Human CBX5. Recombinant protein control fragment (Product #RP-91590). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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