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Gibco™ Human HGF Recombinant Protein

Product Code. 12073599
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Quantity:
10 μg
100 μg
Unit Size:
100µg
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Product Code. 12073599

Brand: Gibco™ PHG0321

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This item is not returnable. View return policy

Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile PBS containing 0.1% human serum albumin. Apportion the reconstituted protein into working aliquots and store at = -20°C. Make any further dilutions of the reconstituted protein in low endotoxin medium or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA. Storage: Store the lyophilized protein at = -20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at = -20°C. Avoid repeated freeze-thaw cycles.

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P14210, Q08048
For Use With (Application) Bioactivity
Formulation PBS with no preservative
Gene ID (Entrez) 15234, 3082
Molecular Weight (g/mol) 70 kDa
Name Human HGF
Purification Method Purified
Quantity 100 μg
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <0.15 EU/μg
Gene Alias C230052L06Rik; DFNB39; Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; F-TCF; hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain; Hepatopoeitin A; hepatopoeitin-A; HepatopoietinA; hepatopoietin-A; Hgf; HGF/SF; HGFB; HPTA; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; NK1; NK2; Scatter factor; scatter factor); SF; SF/HGF
Common Name HGF
Gene Symbol Hgf
Biological Activity ED50 ≤ 20 ng/mL; determined by the dose-dependent proliferation of 4 MBr-5 cells.
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Content And Storage -20°C
Classification Carrier-Free
Activity ED50 ≤ 20 ng/mL; determined by the dose-dependent proliferation of 4MBr-5 cells.
Bioassay Proliferation of the monkey epithelial cell line 4 MBr-5
Endotoxin Level <1 EU/ml
Shipping Condition Dry Ice
Expression System HEK293 cells
Protein Family Growth Factors & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype HGF (Hepatocyte Growth Factor)
Research Category Cell Cycle & Proliferation, Oncology, Stem Cell Research, Signal Transduction, Angiogenesis
Purity or Quality Grade >95% by SDS-PAGE
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