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Invitrogen™ HERPUD1 Polyclonal Antibody

Product Code. 13463457
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
13463457 100 μL 100µL
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Product Code. 13463457 Supplier Invitrogen™ Supplier No. PA529469

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, mouse brain. Predicted reactivity: Mouse (86%), Rat (83%), Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HERPUD1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene HERPUD1
Gene Accession No. Q15011, Q9JJK5
Gene Alias Herp; HERPUD1; homocysteine inducible ER protein with ubiquitin like domain 1; homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; KIAA0025; Methyl methanesulfonate (MMF)-inducible fragment protein 1; Mif1; Mifl; MMS-inducible; Sup
Gene Symbols HERPUD1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human HERPUD1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64209, 9709
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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