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Invitrogen™ GMPS Polyclonal Antibody

Product Code. 17177703
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Quantity:
100 μL
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100µL
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17177703 100 μL 100µL
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DTELIRKLRE EGKVIEPLKD FHKDEVRILG RELGLPEELV SRHPFPGPGL AIRVICAEEP YICKDFPETN NILKIVADFS ASVKKPHTLL QRVKACTTEE DQEKLMQITS LHSLNAFLLP IKTVGVQGDC RSYSYVCGIS SKDEPDWESL IFLARLIPRM CHNVNRVVYI FGPPVKEPPT DVTPTFLTTG VLSTLRQADF EAHNILRESG YAGKISQMPV ILTPLHFDRD PLQKQPSCQR SVVIRTFITS DFMTGIPATP GNEIPVEVVL KMVTEIKKIP GISRIMYDLT SKPPGTTEWE.

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GMPS
Applications ELISA, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 2.69 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GMPS
Gene Accession No. P49915, Q3THK7, Q4V7C6
Gene Alias AA591640; AI047208; Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; GMPS; guanine monophosphate synthase; guanine monophosphate synthetase; guanine monphosphate synthase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion protein; testicular tissue protein Li 82
Gene Symbols GMPS
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 394-693 of human GMPS (NP_003866.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 229363, 295088, 8833
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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