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Invitrogen™ FK506 Monoclonal Antibody (4C12)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA549653
This item is not returnable.
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Description
Antibody tested in indirect ELISA.
Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].
Specifications
| FK506 | |
| Monoclonal | |
| 4.2 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| Mouse | |
| Protein G | |
| RUO | |
| Chemical | |
| Antibody | |
| IgG |
| ELISA, Immunohistochemistry, Lateral Flow, SDS-Page | |
| 4C12 | |
| Unconjugated | |
| C44H69NO12; FK-506; Fujimycin; Tacrolimus | |
| Conjugate of TRL hapten and KLH. | |
| 200 μg | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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