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Description
Recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, and is translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Host Species: Rabbit
Clone: SP1
Isotype: IgG
Species Reactivity: Human, Mouse and Hamster. Others not tested.
Epitope: C-terminus
Immunogen: Synthetic peptide derived from C-terminal of human estrogen receptor
Molecular Weight: 67 kDa
Positive Control: Breast CA, MCF-7 cells
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence (Not verified)
- Flow Cytometery (Not verified)
Specifications
Specifications
| Antigen | Estrogen Receptor (SP1) |
| Applications | Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot |
| Classification | Monoclonal |
| Clone | SP1 |
| Conjugate | Unconjugated |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide derived from C-terminal of human estrogen receptor |
| Quantity | 1 mL |
| Regulatory Status | IVD |
| Research Discipline | Steroids Hormones and Growth Factors |
| Show More |
Product Title
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