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Description
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5′- CANNTG-3′. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
Specifications
Specifications
| Antigen | E2A |
| Applications | Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.6 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | TCF3 |
| Gene Accession No. | P15806, P15923, P21677 |
| Gene Alias | bHLHb21, E2A, E47, ITF1, Kappa E2 binding factor, TCF 3, TCF3, Transcription factor 3, Transcription factor E2 alpha, Transcription factor ITF 1 |
| Gene Symbols | Tcf3 |
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Product Title
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