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  6. DOK6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

DOK6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16812604 Shop All Proteintech Products
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150 μL
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16812604 20 μL 20µL
16802604 150 μL 150µL
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Product Code. 16812604 Supplier Proteintech Supplier No. 141081AP20UL

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Description

Rabbit Polyclonal Antibody

DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predomitly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072-81. Epub 2004 Jul 30. It is also known as DOK6, HsT3226, MGC20785 or IRS. 0.

Specifications

Antigen DOK6
Applications Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DOK6
Gene Accession No. Q2MHE5, Q6PKX4
Gene Alias docking protein 6, DOK5L, DOK6, HsT3226
Gene Symbols Dok6
Host Species Rabbit
Immunogen DOK6 Fusion Protein Ag5254
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 220164, 498898, 623279
Target Species Rat, Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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