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Darusentan, MedChemExpress

Product Code. 16452587
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Product Code. 16452587 Supplier Medchem Express Supplier No. HY15404

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Description

MedChemExpress Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM.

Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM.

Specifications

Chemical Name or Material Darusentan
Physical Form Solid
CAS 171714-84-4
Color White
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C22H22N2O6
For Use With (Application) COVID-19-immunoregulation
Synonym Lu-135252
Solubility Information DMSO : 100 mg/mL (243.65 mM; Need ultrasonic)
SMILES COC1=NC(O[C@H](C(O)=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)=NC(OC)=C1
Molecular Weight (g/mol) 410.42
Formula Weight 410.42
Percent Purity 98.66%
Grade Research
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Research purposes only

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