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Invitrogen™ Cyclin C Polyclonal Antibody

Description
Immunogen sequence: GNFWQSSHYL QWILDKQDLL KERQKDLKFL SEEEYWKLQI FFTNVIQALG E Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.
Specifications
Specifications
| Antigen | Cyclin C |
| Applications | Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.05 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | CCNC |
| Gene Accession No. | P24863 |
| Gene Alias | AI451004; AU020987; CCNC; CG1C; CycC; cyclin C; cyclin-C; dJ199J3.4 (cyclin C); hSRB11; SRB11 homolog |
| Gene Symbols | CCNC |
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