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Invitrogen™ CRALBP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand: Invitrogen™ PA583588

Product Code. 16330545

566.00 EUR / 100µL

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Description

Immunogen sequence: TTKDHGPVFG PCSQLPRHTL QKAKDELNER EETREEAVRE LQEMVQAQAA SGEELAVAVA ERVQEKDSGF FLRFIRARKF NVGRAYELLR GYVNFRL Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 91%.

Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.

Specifications

Antigen	CRALBP
Classification	Polyclonal
Conjugate	Unconjugated
Gene	RLBP1
Gene Alias	3110056M11Rik; cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; CRALBP; retinaldehyde binding protein 1; retinaldehyde-binding protein 1; retinaldehyde-binding protein precursor; Rlbp1
Host Species	Rabbit
Purification Method	Antigen affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	6017
Content And Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form	Liquid

Applications	Immunohistochemistry (Paraffin)
Concentration	0.1 mg/mL
Formulation	PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.	P12271
Gene Symbols	RLBP1
Immunogen	Recombinant protein corresponding to Human RLBP1. Recombinant protein control fragment (Product #RP-106021).
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human
Product Type	Antibody
Isotype	IgG

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Invitrogen™ CRALBP Polyclonal Antibody

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