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Invitrogen™ COPS7A Polyclonal Antibody
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Product Code. 16639534
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Quantity:
100 μL
Unit Size:
100µL
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16639534 100 μL 100µL
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Product Code. 16639534 Supplier Invitrogen™ Supplier No. PA5103079

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total COPS7A.

The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I B-alpha and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COPS7A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene COPS7A
Gene Accession No. Q9CZ04, Q9UBW8
Gene Alias COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana); COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; COP9 complex subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A; COP9 signalosome complex subunit 7a; COP9 signalosome subunit 7A; COPS7A; CSN7; CSN7A; D6Ertd35e; dermal papilla-derived protein 10; DERP10; JAB1-containing signalosome subunit 7a; SGN7a; signalosome subunit 7a
Gene Symbols COPS7A
Host Species Rabbit
Immunogen A synthesized peptide derived from human COPS7A(Accession Q9UBW8), corresponding to amino acid residues D234-N275.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26894, 312710, 50813
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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