Invitrogen™ COL6A1 Polyclonal Antibody

Description

Positive test controls include: SKOV3, HepG2, HT-1080, Mouse heart, Mouse lung, Mouse pancreas. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space. Immunogen sequence: AQDEPETPRA VAFQDCPVDL FFVLDTSESV ALRLKPYGAL VDKVKSFTKR FIDNLRDRYY RCDRNLVWNA GALHYSDEVE IIQGLTRMPG GRDALKSSVD AVKYFGKGTY TDCAIKKGLE QLLVGGSHLK ENKYLIVVTD GHPLEGYKEP CGGLEDAVNE AKHLGVKVFS VAITPDHLEP RLSIIATDHT YRRNFTAADW GQSRDAEEAI SQTIDTIVDM IKNNVEQVCC SF.

The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (typesI, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function.