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Invitrogen™ CDK8 Polyclonal Antibody
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Product Code. 17267763 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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17267763 100 μL 100µL
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Product Code. 17267763 Supplier Invitrogen™ Supplier No. PA5115001

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CDK8.

CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK8
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Cdk8
Gene Accession No. P49336, Q8R3L8
Gene Alias Cdk8; CDK8 protein kinase; cell division protein kinase 8; Cell division protein kinase 8-like protein; cyclin dependent kinase 8; cyclin-dependent kinase 8; K35; mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; protein kinase K35; RGD1560888; wu:fk95h11
Gene Symbols Cdk8
Host Species Rabbit
Immunogen A synthesized peptide derived from human CDK8(Accession P49336), corresponding to amino acid residues E14-C64.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1024, 264064, 498140
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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