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  6. Invitrogen™ CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE, eBioscience™, Invitrogen™

Invitrogen™ CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE, eBioscience™, Invitrogen™
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Product Code. 16380604
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16380604 100 Tests Pack of 100
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Product Code. 16380604 Supplier Invitrogen™ Supplier No. 12365942

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Description

Mouse Monoclonal Antibody

Description: This 1D12-TIM1 monoclonal antibody recognizes human CD365 also known as Tim-1, Kim-1 or Havcr1. This antibody was generated using the immunoglobulin V domain of the extracellular part of the CD365 receptor, and is predicted to recognize all three haplotypes of human CD365. Clone 1D12-TIM1 has been shown to block entry of HCV virus into human hepatoma Huh7.5 cells in a dose dependent manner. It has been also shown to block the uptake of apoptotic cells by CD365-expressing 769-P cells. Applications Reported: This 1D12-TIM1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1D12-TIM1 antibody has been pre-diluted and tested by flow cytometric analysis of A549 cells. This may be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD365 (TIM1)
Applications Flow Cytometry
Classification Monoclonal
Clone 1D12-TIM1
Concentration 5 μL/Test
Conjugate PE
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Havcr1
Gene Accession No. Q96D42
Gene Alias AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Gene Symbols Havcr1
Host Species Mouse
Immunogen IgV domain of human CD365.
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26762
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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