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CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
2985.00 EUR - 14910.00 EUR
Specifications
| Antigen | CD223 (LAG-3) |
|---|---|
| Clone | eBioC9B7W (C9B7W) |
| Concentration | 1 mg/mL |
| Applications | ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization |
| Classification | Monoclonal |
Description
The eBioC9B7W MAb recognizes mouse CD223 (LAG-3, LAG3) protein expressed by activated alpha/beta-TCR bearing T cells, a subset of gamma/delta-TCR bearing T cells and a subset of NK cells. CD223 is a 70 kDa type I transmembrane protein with a structure that is similar to CD4. However, a soluble form of human CD223 has been detected by ELISA in human serum, and data suggest that mouse CD223 is proteolytically cleaved in the D4 domain. This results in a 54 kDa fragment containing all the extracellular domains, and a 16 kDa fragment containing the intracellular and transmembrane domains. The 54 kDa can remain membrane-associated or be released as soluble CD223. CD223 binds to MHC class II with higher affinity than CD4, and it is thought that this interaction is involved in the negative regulation of T-cell activation and homeostatic proliferation. Furthermore, CD223 is expressed by CD4+CD25+ regulatory T cells, and it has been suggested that CD223 may be involved in their regulatory function.
CD223 (LAG-3) Monoclonal antibody specifically detects CD223 (LAG-3) in Mouse samples. It is validated for ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation, NeutralizationSpecifications
| CD223 (LAG-3) | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with no preservative; pH 7.2 | |
| Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; Lag3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
| eBioC9B7W (C9B7W) | |
| ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization | |
| Functional Grade | |
| Rat | |
| Mouse | |
| Q61790 | |
| 16768 | |
| Primary | |
| 4° C | |
| LAG3 |
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