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PeproTech CCL3 Polyclonal Antibody, PeproTech®, Invitrogen™

Product Code. 17813773
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50µg
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17813773 50 μg 50µg
17823703 100 μg 100µg
17863173 1 mg 1mg
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Product Code. 17813773 Supplier PeproTech Supplier No. 500P7750UG

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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Rat MIP-1alpha (CCL3). Anti-Rat MIP-1alpha (CCL3)-specific antibody was purified by affinity chromatography employing an immobilized Rat MIP-1alpha (CCL3) matrix. Sandwich ELISA: To detect Rat MIP-1alpha (CCL3) by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Rat MIP-1alpha (CCL3) (500-P77Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Rat MIP-1alpha (CCL3). Western Blot: To detect Rat MIP-1alpha by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Rat MIP-1alpha is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCL3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Ccl3
Gene Accession No. P50229
Gene Alias AI323804; C-C motif chemokine 3; C-C motif chemokine ligand 3; CCL3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; Heparin-binding chemotaxis protein; H-MIP-1-alpha; L2G25B; LD78ALPHA; LD78-alpha; LD78-alpha(4-69); Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP1 (a); mip1 alpha; MIP-1 alpha; MIP1-(a); MIP1A; MIP-1a; MIP-1alpha; MIP-1-alpha; MIP1-alpha; MIP-1-alpha(4-69); PAT 464.1; RP23-320E6.7; Scya3; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5
Gene Symbols Ccl3
Host Species Rabbit
Immunogen E.coli-derived Recombinant Rat MIP-1alpha (CCL3).
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25542
Target Species Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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