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Capmatinib, MedChemExpress

Product Code. p-200099737
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Product Code. 16491827

Brand: Medchem Express HY13404

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Description

MedChemExpress Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM).

Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase.

Specifications

Chemical Name or Material Capmatinib
CAS 1029712-80-8
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C23H17FN6O
Quantity 50 mg
Synonym INC280 INCB28060
Solubility Information DMSO : 25 mg/mL (60.62 mM; Need ultrasonic) ∣H2O : 10 mg/mL (24.25 mM; Need ultrasonic)
SMILES O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F
Molecular Weight (g/mol) 412.42
Formula Weight 412.42
Percent Purity 98.13%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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