missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Fluorobenzenes
  8. Avapritinib, MedChemExpress

Avapritinib, MedChemExpress

Product Code. 16486137
Encompass_Preferred
Change view
Click to view available options
Quantity:
1 mg
5 mg
10 mg
25 mg
50 mg
100 mg
Unit Size:
100mg
10mg
1mg
25mg
50mg
5mg
6 product options available for selection
Product selection table with 6 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
16486137 5 mg 5mg
16494636 100 mg 100mg
16479936 50 mg 50mg
16423418 10 mg 10mg
16422766 25 mg 25mg
16410779 1 mg 1mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 6 options available.
6 options
This item is not returnable. View return policy
Product Code. 16486137 Supplier Medchem Express Supplier No. HY101561

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

MedChemExpress Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2.

Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2.

Specifications

Chemical Name or Material Avapritinib
CAS 1703793-34-3
Color Off-White
Purity Grade Notes Research
Molecular Formula C26H27FN10
Quantity 5 mg
Synonym BLU-285
Solubility Information DMSO : ≥ 83.33 mg/mL (167.14 mM)
SMILES CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1
Molecular Weight (g/mol) 498.56
Formula Weight 498.56
Percent Purity 99.46%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
Show More Show Less

Research purposes only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.