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TIAR Mouse, Unlabeled, Clone: 6, BD

Product Code. 15895409
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Quantity:
50 μg
Unit Size:
1 set
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15895409 50 μg 1 set
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Product Code. 15895409 Supplier BD Biosciences Supplier No. 610352

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Description

Mouse Monoclonal Antibody

TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus tothe cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.

TRUSTED_SUSTAINABILITY

Specifications

Antigen TIAR
Applications Western Blot
Classification Monoclonal
Clone 6
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Frog, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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