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Stat4 (pY693) Mouse, Unlabeled, Clone: 38/P-STAT4, BD
Mouse Monoclonal Antibody
316.28 EUR - 557.41 EUR
Specifications
| Antigen | Stat4 (pY693) |
|---|---|
| Clone | 38/P-STAT4 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15826279
|
BD Biosciences
612738 |
50 μg |
 317.00 EUR 316.28 EUR / Each Save 0.72 EUR 0.23% Off |
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|
15836279
|
BD Biosciences
612739 |
150 μg |
560.00 EUR 557.41 EUR / Each Save 2.59 EUR 0.46% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNγ in response to treatment with IL-12. IFNγ plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
Western Blotting
Specifications
| Stat4 (pY693) | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2b κ | |
| Affinity Purified |
| 38/P-STAT4 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Mouse | |
| Phosphorylated Human Stat4 (pY693) | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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