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Phospho-p21 (Thr145) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Product Code. 15504001
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Quantity:
100 μL
Unit Size:
100µL
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15504001 100 μL 100µL
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Product Code. 15504001 Supplier Invitrogen Supplier No. PA536677

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 44 kDa. Purity is >95% by SDS-PAGE.

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-p21 (Thr145)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide; pH 7.2
Gene CDKN1A
Gene Accession No. P38936, P39689
Gene Alias Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Gene Symbols CDKN1A
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human p21 around the phosphorylation site of Threonine 145
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1026, 114851, 12575
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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