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JNKK Mouse anti-Human, Unlabeled, Clone: G282-114, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 554105
This item is not returnable.
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Description
JNKK (JNK kinase) is a member of the mitogen-activated protein kinase (MAPK) kinase family. MAPKK family members are components of key signal transduction cascades that link events at the cell surface to responses in the nucleus. MAPK signaling cascades are found in species as varied as yeast and humans with many of the proteins being well conserved. Members of the MAPK family are activated by dual phosphorylation on threonine and tyrosine in response to a variety of extracellular stimuli. Activation of the JNK (Jun N- terminal kinase)/SAPK (stress-activated protein kinase) MAPK pathway occurs in response to factors that cause stress to the cell, and leads to Jun induced transcription. In this protein kinase cascade, MEKK (MAPK kinase kinase) phosphorylates JNKK, JNKK phosphorylates JNK, and JNK phosphorylates Jun. Phosphorylation increases the transcriptional activity of Jun. JNKK migrates at 45kDa in SDS-PAGE. Clone G282-114 recognizes human JNKK. It may cross-react with other kinases in the MAP kinase pathway.
Host Species: Mouse
Clone: G282-114
Isotype: IgG1
Species Reactivity: Human
Immunogen: Recombinant Human JNKK
Formula Weight [Chemical]: 45kDa
Immunoprecipitation, Western Blotting
Specifications
| JNKK | |
| Monoclonal | |
| 0.5mg/mL | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Recombinant Human JNKK | |
| 0.1 mg | |
| Cell Biology | |
| Human | |
| IgG1 |
| Western Blot | |
| G282-114 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
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