Invitrogen™ ACE Polyclonal Antibody

Description

In direct ELISAs, less than 10% cross-reactivity with recombinant mouse ACE is observed and less than 5% cross-reactivity with recombinant human ACE-2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.