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Alpha E catenin Mouse anti-Human, Mouse, Clone: 2B7B8, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66221-1-IG-150UL
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Description
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.Specifications
| Alpha E catenin | |
| Monoclonal | |
| 2.08 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P26231, P35221 | |
| CTNNA1 | |
| Alpha E catenin Fusion Protein Ag23603 | |
| 150 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| 2B7B8 | |
| Unconjugated | |
| CTNNA1 | |
| Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1 | |
| Mouse | |
| Protein G | |
| RUO | |
| 12385, 1495 | |
| -20°C | |
| Liquid |
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