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Invitrogen™ alpha/beta Tubulin Monoclonal Antibody (TU-10)

Product Code. 11514652
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
11514652 100 μg 100µg
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Product Code. 11514652 Supplier Invitrogen™ Supplier No. MA119400

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Description

Mouse Monoclonal Antibody

This antibody recognizes alpha, beta-tubulin heterodimer, a basic intracellular structural unit of microtubules. Alpha- and beta-tubulins form approximately 100 kDa tubulin heterodimer, a globular protein that polymerizes to form microtubules. Western Blot: Reducing conditions.

Tubulin protein is the major constituent of microtubules. Tubulin is a dimer of alpha and beta chains, which binds two molecules of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. There are at least six isotypes of both alpha- and beta- tubulin in human cells, which are distinguished by slightly different amino acid sequences and encoded by a large, multigene family that has been highly conserved throughout evolution. Although the most important functions of microtubules in proliferative cells are through their actions as components of the mitotic spindle, they are also involved in many other essential functions throughout the cell cycle of both malignant and nonmalignant cells. Anti-microtubule agents including Vinca alkaloids and taxanes may disrupt many of these essential functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha/beta Tubulin
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone TU-10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 15mM sodium azide; pH 8
Gene TUBB
Gene Accession No. A2AQ07, P02550, P07437, P68369, P68370, Q71U36, Q767L7, Q9H4B7
Gene Alias 2810484G07Rik; Alpha-tubulin 1; Alpha-tubulin 3; Alpha-tubulin isotype M-alpha-1; B-ALPHA-1; beta 5-tubulin; beta Ib tubulin; CDCBM6; CSCSC1; Detyrosinated tubulin alpha-1A chain; FLJ30169; H2 ALPHA; hum-a-tub1; hum-a-tub2; LIS3; M(beta)1; M40; OK/SW-cl.56; Talpha1 alpha-tubulin; Tuba1; Tuba-1; TUBA1A; TUBA3; TUBB; TUBB1; TUBB2A; TUBB5; Tubulin alpha; tubulin alpha 1a; tubulin alpha 3; tubulin alpha-1 chain; Tubulin alpha-1A chain; tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin beta; tubulin beta 1 class VI; tubulin beta chain; tubulin beta class I; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, alpha 1; tubulin, alpha 1A; tubulin, alpha, brain-specific; tubulin, beta 1 class VI; tubulin, beta 2A class IIa; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; α/β-tubulin
Gene Symbols TUBA1A, TUBB, TUBB1
Host Species Mouse
Immunogen Microtubule proteins from porcine brain.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100134983, 100135051, 203068, 22142, 545486, 64158, 679312, 733686, 7846, 81027
Target Species Human, Multi-species, Mouse, Pig, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgM
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