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ALOX5 Monoclonal Antibody (OTI2C7), TrueMAB™, OriGene

Product Code. 17527343
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100 μL
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30µL
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17527343 100 μL 100µL
17547343 30 μL 30µL
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Product Code. 17527343 Supplier Origene Technologies Supplier No. TA807012

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Description

Mouse Monoclonal Antibody

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT ). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.

Specifications

Antigen ALOX5
Applications Western Blot
Classification Monoclonal
Clone OTI2C7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene ALOX5
Gene Accession No. P09917
Gene Alias 5-LO, 5-LOX, 5LPG, LOG5
Gene Symbols ALOX5
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 18-364 of human ALOX5 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 240
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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