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Almonertinib hydrochloride, MedChemExpress

Product Code. 16495536
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Product Code. 16495536

Brand: Medchem Express HY112823B

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Description

MedChemExpress Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations.

Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer.

Specifications

Chemical Name or Material Almonertinib hydrochloride
CAS 2134096-03-8
Color Off-White
Purity Grade Notes Research
Molecular Formula C30H36ClN7O2
Quantity 100 mg
Synonym HS-10296 hydrochloride
Solubility Information DMSO : 83.33 mg/mL (148.25 mM; Need ultrasonic)
SMILES COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.[H]Cl
Molecular Weight (g/mol) 562.11
Formula Weight 562.11
Percent Purity 98.03%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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