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  7. A-317491 sodium salt hydrate, MedChemExpress

A-317491 sodium salt hydrate, MedChemExpress

Product Code. 16489197
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Product Code. 16489197 Supplier Medchem Express Supplier No. HY15568A

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Description

MedChemExpress A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively.

A-317491 sodium salt hydrate is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

Specifications

Chemical Name or Material A-317491 sodium salt hydrate
Color Off-White
Purity Grade Notes Research
Molecular Formula C33H29NNaO9
Quantity 5 mg
Solubility Information H2O : ≥ 100 mg/mL (164.86 mM) ∣DMSO : ≥ 100 mg/mL (164.86 mM)
SMILES O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O.[Na].O
Molecular Weight (g/mol) 606.57
Formula Weight 606.57
Percent Purity 99.63%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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