Widespread expression of CD117 in hematopoietic precursors is consistent with participation of c-Kit and its ligand in regulation of several hematopoietic lineages. BD Horizon™ BV480 Rat Anti-Mouse CD117 is also involved in the regulation of some events during the development of T lymphocytes. CD117 is also expressed by mast cells and by dendritic cells found in the periarteriolar lymphocytoc sheaths (T-cell areas) of splenic white pulp.