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VEGF Receptor 1 (Flt1) Rat anti-Human, Clone: 7A6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5936-80

Additional Details : Weight : 0.01000kg

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Product Code. 15257607

  • 103.00 EUR / 25µg


Estimated Shipment date
from Supplier 22-10-2019
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Description

Description

Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
Specifications

Specifications

VEGF Receptor 1 (Flt1)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P17948
FLT, VEGFR1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
7A6
Unconjugated
FLT1
Liquid
FLT1
IgG2a
25 μg
4° C
Primary
2321
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