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TCR V beta 8.1/8.2 Rat anti-Mouse, FITC, Clone: KJ16-133 (KJ-16, KJI6, KJ-I6), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-5813-81

Additional Details : Weight : 0.25000kg

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Product Code. 15258269

  • 89.25 EUR / 50µg


Estimated Shipment date
from Supplier 22-10-2019
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Description

Description

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR V beta 8.1/8.2
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
TCRV beta 8.1; TCRV beta8.1; TCR V beta8.1; TCR V beta8.2; Vb8.1; Vbeta8.1; Vb8.2; Vbeta8.2
IgG2a, kappa
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
Mouse
Flow Cytometry
KJ16-133 (KJ-16, KJI6, KJ-I6)
FITC
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
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