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TSLP Rat anti-Mouse, Functional Grade, Clone: eBio28F12 (28F12), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-5491-82

Additional Details : Weight : 0.01000kg

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Product Code. 15258647

  • 109.00 EUR / 100µg


Estimated Shipment date
from Supplier 27-09-2019
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Description

Description

Applications Tested: The ND50 of eBio28F12, as determined by the neutralization of recombit mouse TSLP-induced proliferation of the Nag8/7 cell line, is 1-3 ng/mL in the presence of 0.5 ng/mL mTSLP. The neutralization dose of this antibody will vary depending on cell type, assay method, and cytokine concentration. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintece of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
Specifications

Specifications

TSLP
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
Q9JIE6
thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Functional Assay, Neutralization
eBio28F12 (28F12)
Functional Grade
Tslp
Liquid
Tslp
IgG2a, kappa
100 μg
4° C
Primary
53603
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