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TNF alpha, Functional Grade, clone: MP6-XT3, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-7322-81

Additional Details : Weight : 0.01000kg

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Product Code. 15288797

  • 89.25 EUR / 50µg


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Description

Description

Aggregation: Less than 10%, as determined by HPLC. TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Specifications

Specifications

TNF alpha
Monoclonal
1 mg/mL
antibody with 20mM arginine, 50mM citrate and no preservative; pH 6.4
P06804
DADB-70P7.1, DIF, TNF-alpha, TNFA, TNFSF2
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Functional Assay, Neutralization
MP6-XT3
Functional Grade
Tnf
Liquid
Tnf
IgG1, kappa
50 μg
4° C
Primary
21926
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