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Thiazovivin, Tocris Bioscience™

Product Code. 18045212
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Quantity:
10 mg
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This item is not returnable. View return policy

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.

Specifications

CAS 1226056-71-8
Molecular Formula C15H13N5OS
Quantity 10 mg
Synonym thiazovivin, n-benzyl-2-pyrimidin-4-ylamino thiazole-4-carboxamide, n-benzyl-2-pyrimidin-4-ylamino-1,3-thiazole-4-carboxamide, n-benzyl-2-pyrimidin-4-ylamino-thiazole-4-carboxamide, n-phenylmethyl-2-4-pyrimidinylamino-4-thiazolecarboxamide, pubchem24336, n-benzyl-2-pyrimidin-4-yl amino thiazole-4-carboxamide, benzyl-2-pyrimidin-4-ylamino thiazole-4-carboxamide, n-benzyl-2-pyrimidin-4-yl amino-1,3-thiazole-4-carboxamide, 4-thiazolecarboxamide, n-phenylmethyl-2-4-pyrimidinylamino
InChI Key DOBKQCZBPPCLEG-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
IUPAC Name N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
Molecular Weight (g/mol) 311.363
PubChem CID 46209426
Formula Weight 311.36
Percent Purity 98%
Chemical Name or Material Thiazovivin
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