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Staurosporine, MP Biomedicals™
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Quantity:
1 mg
500 μg
Description
Starosporin is used to study the involvement of protein kinases in signal transduction pathways. It arrests normal cells in the G1 checkpoint and is a potent inhibitor of Protein kinase C and other protein kinases in vitro and in cultured cells. It is an inducer of apoptosis in many mammalian cell types.
- Potent inhibitor of phospolipid/calcium dependent and cyclic nucleotide dependent protein kinases
- Useful as a tool for studies on protein phosphorylation in the regulation of cellular functions
- Inhibits the upregulation of VEGF expression in tumor cells
- Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents
- Inhibits Pgp phosphorylation (functional significance of Pgp phosphorylation is ill defined)
Specifications
Physical Form | Powder |
Melting Point | 237°C |
Solubility Information | May be reconstituted by dissolving the lyophilized reagent in DMSO (5mg/mL, clear, colorless solution), DMF, ethyl acetate (5mg/mL, clear colorless solution) or methanol or water. |
Formula Weight | 466.5 |
Percent Purity | ≥98% |
Quantity | 500 μg |
Safety and Handling
Product Identifier
- Staurosporine
- Danger
- Carcinogenicity Category 1B
- Germ cell mutagenicity Category 1B
- H340-May cause genetic defects.
- H350-May cause cancer.
- P101-If medical advice is needed, have product container or label at hand.
- P102-Keep out of reach of children.
- P103-Read label before use.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : Staurosporine
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