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SF3A1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA556334
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: YPPPEVRNIV DKTASFVARN GPEFEARIRQ NEINNPKFNF LNPNDPYHAY YRHKVSEFKE GKAQEPSAAI PKVMQQQQQT TQQQLPQKVQ AQVIQETIVP KEPPPEFEFI ADPPSISAFD LDVVKLTAQF VARNGRQFLT QLMQKEQRNY QFDFLRPQHS LFNYFTKLVE QYTKI Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.Specifications
SF3A1 | |
Polyclonal | |
Unconjugated | |
Sf3a1 | |
1200014H24Rik; 5930416L09Rik; AI159724; pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; Sf3a1; sf3a1 protein; SF3A120; si:dz150f13.2; spliceosome-associated protein 114; splicing factor 3 subunit 1; splicing factor 3A subunit 1; splicing factor 3a, subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa; Unknown (protein for MGC:65786); wu:fc38e01; wu:fc50a11; wu:fj37c05; zgc:65786 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
10291 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q15459 | |
Sf3a1 | |
Recombinant protein corresponding to Human SF3A1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only