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  7. SC 514, Tocris Bioscience™

SC 514, Tocris Bioscience™

Catalog Number 18085512
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
354812-17-2
C9H8N2OS2
224.296
BMUACLADCKCNKZ-UHFFFAOYSA-N
3-amino-5-thiophen-3-yl thiophene-2-carboxamide, 4-amino-2,3'-bithiophene-5-carboxamide, ikk-2 inhibitor, sc-514, insolution ikk-2 inhibitor, sc-514, 5-thien-3-yl-3-aminothiophene-2-carboxamide, curator_000007, 4-amino-2,3-bithiophene-5-carboxamide, biomolki_000076, biomolki2_000080, d0t6va
2807869
3-amino-5-thiophen-3-ylthiophene-2-carboxamide
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
This item is not returnable. View return policy
354812-17-2
C9H8N2OS2
224.296
BMUACLADCKCNKZ-UHFFFAOYSA-N
3-amino-5-thiophen-3-yl thiophene-2-carboxamide, 4-amino-2,3'-bithiophene-5-carboxamide, ikk-2 inhibitor, sc-514, insolution ikk-2 inhibitor, sc-514, 5-thien-3-yl-3-aminothiophene-2-carboxamide, curator_000007, 4-amino-2,3-bithiophene-5-carboxamide, biomolki_000076, biomolki2_000080, d0t6va
2807869
3-amino-5-thiophen-3-ylthiophene-2-carboxamide
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N

Description

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8 μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.
Quantity 10 mg
Formula Weight 224.3
Percent Purity >98%
Chemical Name or Material SC 514
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