Invitrogen™ Human S1P1 Synthetic Peptide

Description

S1P1 Synthetic Peptide, PEP-0730, from Invitrogen.

S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis. This peptide corresponds to 14 amino acids near the carboxy terminus of human S1P1.PEP-0730 can be used as a blocking peptide with polyclonal antibody PA5-20610.